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Article

Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders.

The Journal of investigative dermatology - 1 May 2012

Lessard Juliane C, Coulombe Pierre A

Abstract excerpt

Keratin 16 (KRT16 in human, Krt16 in mouse), a type I intermediate filament protein, is constitutively expressed in epithelial appendages and is induced in the epidermis upon wounding and other stressors. Mutations altering the coding sequence of KRT16 cause pachyonychia congenita (PC), a rare autosomal dominant disorder characterized by hypertrophic nail dystrophy, oral leukokeratosis, and palmoplantar...

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Identifiers

PMID: 22336941
DOI: 10.1038/jid.2012.6
PMCID: PMC3326191

Genes

KRT16

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Related research

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Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders.PMID 22336941Read ↗

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