Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype.

The international journal of neuropsychopharmacology - 1 Feb 2008

Guiard Bruno P, David Denis J P, Deltheil Thierry, Chenu Franck, Le Maître Erwan, Renoir Thibault, Leroux-Nicollet Isabelle, Sokoloff Pierre, Lanfumey Laurence, Hamon Michel, Andrews Anne M, Hen René, Gardier Alain M

Abstract excerpt

Growing evidence supports the involvement of brain-derived neurotrophic factor (BDNF) in mood disorders and the mechanism of action of antidepressant drugs. However, the relationship between BDNF and serotonergic signalling is poorly understood. Heterozygous mutants BDNF +/- mice were utilized to investigate the influence of BDNF on the serotonin (5-HT) system and the activity of the serotonin transporter (SERT)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoradiography
Share to Brain Chemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Citalopram

Share to Microdialysis

Share to Paroxetine

Share to Receptor, Serotonin, 5-HT1A

Share to Selective Serotonin Reuptake Inhibitors

Share to Serotonin Receptor Agonists

Source

Identifiers

PMID: 17559709
DOI: 10.1017/S1461145707007857

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype.PMID 17559709Read ↗

Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice.Semantic proximity Read ↗

Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice.Semantic proximity Read ↗

Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models.Semantic proximity Read ↗

Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans.Semantic proximity Read ↗

The effects of selective serotonin reuptake inhibitors on extracellular 5-HT levels in the hippocampus of 5-HT(1B) receptor knockout mice.Semantic proximity Read ↗

BDNF overexpression in the ventral hippocampus promotes antidepressant- and anxiolytic-like activity in serotonin transporter knockout ratsSemantic proximity Read ↗

BDNF Overexpression in the Prelimbic Cortex Does Not Reduce Anxiety- and Depression-like Behavior in Serotonin Knockout RatsSemantic proximity Read ↗

5-HT(1A) receptor mutant mice exhibit enhanced tonic, stress-induced and fluoxetine-induced serotonergic neurotransmission.Semantic proximity Read ↗

Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandemSemantic proximity Read ↗

Adaption of the serotoninergic neuronal phenotype in the absence of 5-HT autoreceptors or the 5-HT transporter: involvement of BDNF and cAMP.Semantic proximity Read ↗

Characterization of serotonin neurotransmission in knockout mice: implications for major depression.Semantic proximity Read ↗

BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.