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Article

Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans.

Neurobiology of disease - 1 Mar 2010

Molteni Raffaella, Cattaneo Annamaria, Calabrese Francesca, Macchi Flavia, Olivier Jocelien D A, Racagni Giorgio, Ellenbroek Bart A, Gennarelli Massimo, Riva Marco A

Abstract excerpt

In order to identify the molecular mechanisms that may contribute to the enhanced susceptibility to depression under serotonin transporter (SERT) dysfunction, we analyzed the expression of brain-derived neurotrophic factor (BDNF), a key player in neuronal plasticity, which is implicated in the etiology and treatment of depression. We found that BDNF levels were significantly reduced in the hippocampus and...

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Source

Identifiers

PMID: 20034565
DOI: 10.1016/j.nbd.2009.12.014

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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