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JCAD couples tight junction condensates to actin and RhoA to maintain the endothelial barrier

2026-05-21

Abstract excerpt

How endothelial cell-cell junctions integrate cytoskeletal, adhesive, and local signaling networks to maintain vascular barrier integrity remains incompletely defined. Here, we identify junctional cadherin 5-associated protein (JCAD) as a modular scaffold that organizes endothelial tight junction architecture by coupling junctional condensates to actin and RhoA signaling. Genetic deletion of Jcad in mice does not...

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Literature Corpus work
da1a1902-a3b5-5d58-8496-91dc3514f8f4
DOI
10.64898/2026.05.19.725802
Open publication

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JCAD couples tight junction condensates to actin and RhoA to maintain the endothelial barrierDOI 10.64898/2026.05.19.725802
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