Article

TNF-α induces VE-cadherin-dependent gap/JAIL cycling through an intermediate state essential for neutrophil transmigration

2025-07-23

Abstract excerpt

Inflammatory endothelial phenotypes describe distinct cellular patterns essential for controlling transendothelial migration of leukocytes (TEM). While TNF-α-induced CAM expression mediates leukocyte interaction, the role of a potential inflammatory morphological phenotype (IMP) – characterised by barrier-function decrease and shape-change in TEM – remains unclear. This study identifies the TNF-α-induced IMP as in...

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Literature Corpus work: bf74ee4f-f130-5c35-90fd-ce8d3524789f
DOI: 10.1101/2025.07.20.665739

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