Article

Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification

2023-09-10

Abstract excerpt

CRISPR base editing screens are powerful tools for studying disease-associated variants at scale. However, the efficiency and precision of base editing perturbations vary, confounding the assessment of variant-induced phenotypic effects. Here, we provide an integrated pipeline that improves the estimation of variant impact in base editing screens. We perform high-throughput ABE8e-SpRY base editing screens with an...

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Literature Corpus work: da18da7b-78ef-5fe9-8271-591680d4e18a
DOI: 10.1101/2023.09.08.23295253

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