Article

Electrostatic interactions define nacubactam potency against OXA-48-like β-lactamases

2024-10-30

Abstract excerpt

Carbapenemases, β-lactamases hydrolysing carbapenem antibiotics, severely challenge treatment of multi-drug resistant bacterial infections. OXA-48 is among the most widely disseminated carbapenemases in Enterobacterales , consequently new treatment options for OXA-48 producers are urgently required. Development of diazabicyclooctane (DBO) inhibitors to overcome β-lactamase-mediated resistance is one attractive op...

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Literature Corpus work: da180adb-1cc4-580a-bb97-cf7bea8f3fc7
DOI: 10.1101/2024.10.30.621041

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