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Article

Resistance to aztreonam-avibactam due to a mutation of SHV-12 in Enterobacter.

Annals of clinical microbiology and antimicrobials - 26 Jun 2023

Wu Shikai, Ma Ke, Feng Yu, Zong Zhiyong

Abstract excerpt

Aztreonam-avibactam is an important option against Enterobacterales producing metallo-β-lactamases (MBLs). We obtained an aztreonam-avibactam-resistant mutant of an MBL-producing Enterobacter mori strain by induced mutagenesis. Genome sequencing revealed an Arg244Gly (Ambler position) substitution of SHV-12 β-lactamase in the mutant. Cloning and susceptibility testing verified that the SHV-12 Arg244Gly...

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Identifiers

PMID: 37365592
DOI: 10.1186/s12941-023-00605-y
PMCID: PMC10294450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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