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Article

The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma.

Cancer research - 1 Apr 2009

Seiwert Tanguy Y, Jagadeeswaran Ramasamy, Faoro Leonardo, Janamanchi Varalakshmi, Nallasura Vidya, El Dinali Mohamed, Yala Soheil, Kanteti Rajani, Cohen Ezra E W, Lingen Mark W, Martin Leslie, Krishnaswamy Soundararajan, Klein-Szanto Andres, Christensen James G, Vokes Everett E, Salgia Ravi

Abstract excerpt

Recurrent/metastatic head and neck cancer remains a devastating disease with insufficient treatment options. We investigated the MET receptor tyrosine kinase as a novel target for the treatment of head and neck squamous cell carcinoma (HNSCC). MET/phosphorylated MET and HGF expression was analyzed in 121 tissues (HNSCC/normal) by immunohistochemistry, and in 20 HNSCC cell lines by immunoblotting. The effects of...

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Identifiers

PMID: 19318576
DOI: 10.1158/0008-5472.CAN-08-2881
PMCID: PMC2871252

Genes

MET
HGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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