Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Opposing roles of glutaminase isoforms in determining glioblastoma cell phenotype.

Neurochemistry international - 1 Sept 2015

Szeliga Monika, Albrecht Jan

Abstract excerpt

Glutamine (Gln) and glutamate (Glu) play pivotal roles in the malignant phenotype of brain tumors via multiple mechanisms. Glutaminase (GA, EC 3.5.1.2) metabolizes Gln to Glu and ammonia. Human GA isoforms are encoded by two genes: GLS gene codes for kidney-type isoforms, KGA and GAC, whereas GLS2 codes for liver-type isoforms, GAB and LGA. The expression pattern of both genes in different neoplastic cell lines...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Cell Line, Tumor
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioblastoma

Share to Glutaminase

Share to Isoenzymes

Share to Phenotype

Source

Identifiers

PMID: 25529918
DOI: 10.1016/j.neuint.2014.11.004

Genes

GLS2
GLS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Opposing roles of glutaminase isoforms in determining glioblastoma cell phenotype.PMID 25529918Read ↗

Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2Semantic proximity Read ↗

A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis.Semantic proximity Read ↗

Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasisSemantic proximity Read ↗

A pan-cancer analysis of the glutaminase and their association with prognosis, tumor microenvironment, and therapeutic targetsSemantic proximity Read ↗

Mitochondrial enzyme GLUD2 plays a critical role in glioblastoma progressionSemantic proximity Read ↗

Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell LinesSemantic proximity Read ↗

Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes.Semantic proximity Read ↗

MiR-513c suppresses neuroblastoma cell migration, invasion, and proliferation through direct targeting glutaminase (GLS)Semantic proximity Read ↗

Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.Semantic proximity Read ↗

Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic CancerSemantic proximity Read ↗

Bioinformatic profiling identifies the glutaminase to be a potential novel cuproptosis-related biomarker for gliomaSemantic proximity Read ↗

Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.