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Identification of CRYAB <sup>+</sup> KCNN3 <sup>+</sup> SOX9 <sup>+</sup> astro-like and EGFR <sup>+</sup> PDGFRA <sup>+</sup> OLIG1 <sup>+</sup> oligo-like tumoral cells in diffuse low-grade gliomas and implication of Notch1 signalling in their genesis

2021-02-11

Abstract excerpt

IDH1-mutated gliomas are slow growing brain tumours, which progress into high-grade gliomas. They present intra-tumoural cell heterogeneity, but no good markers are available to distinguish the different cell subtypes. The molecular mechanisms underlying the formation of this cell diversity is also ill defined. Here we report that the SOX9 and OLIG1 transcription factors, which specifically label astrocytes and ol...

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Literature Corpus work
d9f6843e-4577-5e05-9850-f919e1e4fb6f
DOI
10.1101/2021.02.09.430313
Open publication

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Identification of CRYAB <sup>+</sup> KCNN3 <sup>+</sup> SOX9 <sup>+</sup> astro-like and EGFR <sup>+</sup> PDGFRA <sup>+</sup> OLIG1 <sup>+</sup> oligo-like tumoral cells in diffuse low-grade gliomas and implication of Notch1 signalling in their genesisDOI 10.1101/2021.02.09.430313
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