Article

ARF6 as a novel activator of HIF-2α in pulmonary arterial hypertension

2023-09-15

Abstract excerpt

<h4>ABSTRACT</h4> ADP-ribosylation factor 6 (ARF6), a GTPase associated with cancer metastasis, is activated in the lung endothelium in pulmonary arterial hypertension (PAH). To identify ARF6-regulated pathways relevant to PAH, we performed a state-of-the-art proteomic analysis of human pulmonary artery endothelial cells (HPAECs) overexpressing the wildtype, constitutively active, fast-cycling and dominant negati...

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Literature Corpus work: d9ed358e-46f9-5bbe-a67b-445467d2c5a0
DOI: 10.1101/2023.09.15.557917

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