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Article

Deficiency of fibroblast growth factor 2 promotes contractile phenotype of pericytes in ascending thoracic aortic aneurysm.

American journal of physiology. Heart and circulatory physiology - 1 May 2025

Huang Weijian, Hill Jennifer C, Patel Sakshi, Richards Tara D, Sultan Ibrahim, Kaczorowski David J, Phillippi Julie A

Abstract excerpt

Pericytes exhibit progenitor cell-like qualities and associate with the vasa vasorum-vital microvessels nourishing larger arteries and veins. How pericytes change in human ascending thoracic aortic aneurysm (ATAA) remains unknown. Here, we used the public single-nuclei sequencing data to reveal a contractile phenotype transition of pericytes in human ATAA specimens. In addition, we found that a protective factor,...

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Source

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Identifiers

PMID: 40214073
DOI: 10.1152/ajpheart.00834.2024
PMCID: PMC12172006

Genes

FGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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