Article
Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development.
The European journal of neuroscience - 1 Dec 2009
Zhang Xue-Mei, Cai Yan, Xiong Kun, Cai Huaibin, Luo Xue-Gang, Feng Jia-Chun, Clough Richard W, Struble Robert G, Patrylo Peter R, Yan Xiao-Xin
Abstract excerpt
The presence of neuritic plaques is a pathological hallmark of Alzheimer's disease (AD). However, the origin of extracellular beta-amyloid peptide (Abeta) deposits and the process of plaque development remain poorly understood. The present study attempted to explore plaque pathogenesis by localizing beta-secretase-1 (BACE1) elevation relative to Abeta accumulation and synaptic/neuritic alterations in the...
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