Article

LUC7 proteins define two major classes of 5’ splice sites in animals and plants

2022-12-08

Abstract excerpt

Mutation or deletion of the U1 snRNP-associated factor LUC7L2 is associated with myeloid neoplasms, and knockout of LUC7L2 alters cellular metabolism. Here, we uncover that members of the LUC7 protein family differentially regulate two major classes of 5’ splice sites (5’SS) and broadly regulate mRNA splicing in both human cell lines and leukemias with LUC7L2 copy number variation. We describe distinctive 5’SS fe...

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Literature Corpus work: d9c77845-cd8b-5529-a0b4-e96b9230d95c
DOI: 10.1101/2022.12.07.519539

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