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Sulphiredoxin plays peroxiredoxin‐dependent and ‐independent roles via the HOG signalling pathway in C ryptococcus neoformans and contributes to fungal virulence

3 Sept 2013

Abstract excerpt

Mechanisms of oxidative stress resistance are crucial virulence factors for survival and proliferation of fungal pathogens within the human host. In this study we have identified and functionally characterized the role of sulphiredoxin, Srx1, in oxidative stress resistance of Cryptococcus neoformans causing fungal meningoencephalitis and regulation of peroxiredoxins, Tsa1 and Tsa3, and thioredoxins, Trx1 and...

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PMID: 23998805
DOI: 10.1111/mmi.12388

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