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Differential Impairment Of Cerebrospinal Fluid Synaptic Biomarkers In The Genetic Forms Of Frontotemporal Dementia

2022-03-08

Abstract excerpt

<h4>Background: </h4> Approximately a third of frontotemporal dementia (FTD) is genetic with mutations in three genes accounting for most of the inheritance: C9orf72, GRN and MAPT . Impaired synaptic health is a common mechanism in all three genetic variants and so developing fluid biomarkers of this process could be useful as a readout of cellular dysfunction within therapeutic trials. <h4>Methods: </h4>: A total...

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Literature Corpus work
d994cfbb-fb07-5a1a-8bea-fb677c820b65
DOI
10.21203/rs.3.rs-1188941/v2
Open publication

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Differential Impairment Of Cerebrospinal Fluid Synaptic Biomarkers In The Genetic Forms Of Frontotemporal DementiaDOI 10.21203/rs.3.rs-1188941/v2
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