A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI study.

doi:10.1186/s13024-021-00499-4

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A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI study.

Molecular neurodegeneration - 27 Nov 2021

Bergström Sofia, Öijerstedt Linn, Remnestål Julia, Olofsson Jennie, Ullgren Abbe, Seelaar Harro, van Swieten John C, Synofzik Matthis, Sanchez-Valle Raquel, Moreno Fermin, Finger Elizabeth, Masellis Mario, Tartaglia Carmela, Vandenberghe Rik, Laforce Robert, Galimberti Daniela, Borroni Barbara, Butler Chris R, Gerhard Alexander, Ducharme Simon, Rohrer Jonathan D, Månberg Anna, Graff Caroline, Nilsson Peter

Abstract excerpt

BACKGROUND: A detailed understanding of the pathological processes involved in genetic frontotemporal dementia is critical in order to provide the patients with an optimal future treatment. Protein levels in CSF have the potential to reflect different pathophysiological processes in the brain. We aimed to identify and evaluate panels of CSF proteins with potential to separate symptomatic individuals from...

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Identifiers

PMID: 34838088
DOI: 10.1186/s13024-021-00499-4
PMCID: PMC8626910

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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