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Multiplex plasma profiling of synaptic biomarkers in Alzheimer’s disease using NULISA: early alterations, APOE genotype effects, and pTau217 associations

2026-06-01

Abstract excerpt

<h4>INTRODUCTION</h4> Synaptic markers are altered in the CSF of Alzheimer’s disease (AD) patients, but their quantification in plasma remains challenging. We evaluated plasma synaptic markers in MCI and mild AD using the nucleic acid–linked immuno-sandwich assay (NULISA) and their correlation with APOE genotype. <h4>METHODS</h4> 272 participants (154 CSF-confirmed AD, 118 controls) underwent plasma assessment w...

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Literature Corpus work
08feb973-a998-5a48-9edf-cdc4f98799bd
DOI
10.64898/2026.05.21.26353560
Open publication

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Multiplex plasma profiling of synaptic biomarkers in Alzheimer’s disease using NULISA: early alterations, APOE genotype effects, and pTau217 associationsDOI 10.64898/2026.05.21.26353560
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