Article
Differential impairment of cerebrospinal fluid synaptic biomarkers in the genetic forms of frontotemporal dementia.
Alzheimer's research & therapy - 31 Aug 2022
Sogorb-Esteve Aitana, Nilsson Johanna, Swift Imogen J, Heller Carolin, Bocchetta Martina, Russell Lucy L, Peakman Georgia, Convery Rhian S, van Swieten John C, Seelaar Harro, Borroni Barbara, Galimberti Daniela, Sanchez-Valle Raquel, Laforce Robert, Moreno Fermin, Synofzik Matthis, Graff Caroline, Masellis Mario, Tartaglia Maria Carmela, Rowe James B, Vandenberghe Rik, Finger Elizabeth, Tagliavini Fabrizio, Santana Isabel, Butler Chris R, Ducharme Simon, Gerhard Alexander, Danek Adrian, Levin Johannes, Otto Markus, Sorbi Sandro, Le Ber Isabelle, Pasquier Florence, Gobom Johan, Brinkmalm Ann, Blennow Kaj, Zetterberg Henrik, Rohrer Jonathan D
Abstract excerpt
BACKGROUND: Approximately a third of frontotemporal dementia (FTD) is genetic with mutations in three genes accounting for most of the inheritance: C9orf72, GRN, and MAPT. Impaired synaptic health is a common mechanism in all three genetic variants, so developing fluid biomarkers of this process could be useful as a readout of cellular dysfunction within therapeutic trials. METHODS: A total of 193 cerebrospinal...
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