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Novel CSF biomarkers in genetic frontotemporal dementia identified by proteomics

7 Mar 2019

Abstract excerpt

Abstract Objective To identify novel CSF biomarkers in GRN ‐associated frontotemporal dementia ( FTD ) by proteomics using mass spectrometry ( MS ). Methods Unbiased MS was applied to CSF samples from 19 presymptomatic and 9 symptomatic GRN mutation carriers and 24 noncarriers. Protein abundances were compared between these groups. Proteins were then selected for validation if identified by ≥4 peptides and if...

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PMID: 31019994
DOI: 10.1002/acn3.745

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