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5-hydroxymethylcytosine profiles in circulating cell-free DNA associate with disease status in patients with osteosarcoma

2025-09-01

Abstract excerpt

<title>Abstract</title> <p>5-hydroxymethylcytosine (5-hmC) is a marker of open chromatin and active gene expression. We profiled 5-hmC using plasma-derived cell-free DNA (cfDNA) from patients with osteosarcoma to assess its utility as a biomarker of disease status. Genes with differential 5-hmC levels were identified from a Discovery cohort consisting of patients with osteosarcoma and well children. An independen...

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Literature Corpus work
d9937131-e82a-540d-a7df-5027aec94cb8
DOI
10.21203/rs.3.rs-7199550/v1
Open publication

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5-hydroxymethylcytosine profiles in circulating cell-free DNA associate with disease status in patients with osteosarcomaDOI 10.21203/rs.3.rs-7199550/v1
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