Article

Inactivation of TRPM7 kinase targets AKT signaling and cyclooxygenase-2 expression in human CML cells

2023-01-09

Abstract excerpt

<title>Abstract</title> <p>Cyclooxygenase-2 (COX-2) is a key regulator of inflammation. High constitutive <italic>COX-2</italic> expression enhances survival and proliferation of tumor cells, whereas it adversely impacts anti-tumor immunity. We recently identified the <italic>melastatin-like transient-receptor-potential-7</italic> (TRPM7) protein as modulator of immune homeostasis. TRPM7 is essential for leukocyt...

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Literature Corpus work: 01d73494-d7bd-56e3-b411-bc3d307e4267
DOI: 10.21203/rs.3.rs-2405917/v1

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