Article

Transcriptomic Characterization of Hypermutated Microsatellite Stable Tumors Reveals Distinct Proliferative and Immune Signatures

2026-06-30

Abstract excerpt

<title>Abstract</title> <p>Hypermutated microsatellite stable tumors are a subgroup of cancers, representing approximately 1-2% of colorectal tumors and frequently associated with loss of POLE function. These tumors show increased immunogenicity and biological features similar to microsatellite instability-high tumors. However, their transcriptomic characteristics remain poorly understood. Here, we provide the fi...

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Literature Corpus work: d94bcf86-21d1-564a-bd09-ad7fd1583f89
DOI: 10.21203/rs.3.rs-9942692/v1

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