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Article

Dynamin is functionally coupled to insulin granule exocytosis.

The Journal of biological chemistry - 16 Nov 2007

Min Le, Leung Yuk M, Tomas Alejandra, Watson Robert T, Gaisano Herbert Y, Halban Philippe A, Pessin Jeffrey E, Hou June Chunqiu

Abstract excerpt

The insulin granule integral membrane protein marker phogrin-green fluorescent protein was co-localized with insulin in Min6B1 beta-cell secretory granules but did not undergo plasma membrane translocation following glucose stimulation. Surprisingly, although expression of a dominant-interfering dynamin mutant (Dyn/K44A) inhibited transferrin receptor endocytosis, it had no effect on phogringreen fluorescent...

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Identifiers

PMID: 17848579
DOI: 10.1074/jbc.M703402200

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