Article

Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity

2022-02-08

Abstract excerpt

<h4>ABSTRACT</h4> Hepatic de novo lipogenesis is influenced by the branched-chain α-keto acid dehydrogenase (BCKDH) kinase (BCKDK). We aimed to determine whether circulating levels of the immediate substrates of BCKDH, the branched-chain α-ketoacids (BCKAs) and hepatic BCKDK expression are associated with the presence and severity of non-alcoholic fatty liver disease (NAFLD).Eighty metabolites (3 BCKA, 14 amino ac...

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Literature Corpus work: 3a8e03ed-5fb2-56dd-89fe-a0468e1bc051
DOI: 10.1101/2022.02.07.22270618

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Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesityDOI 10.1101/2022.02.07.22270618Read

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