Article
Demystifying metabolic‒immune crosstalk: how amino acid metabolic reprogramming shapes the malignant phenotype and macrophage polarization of biliary and pancreatic tumors.
International journal of biological sciences - 1 Jan 2025
Zhang Jinglei, Chu Zhuohuan, Li Jiawen, Xie Lu, Ding Cong, An Zihui, Wang Xiang, Jin Hangbin, Zhang Xiaofeng, Liu Qiang, Yang Jianfeng
Abstract excerpt
Biliary and pancreatic malignant tumors refer to biliary tract carcinoma (BTC) and pancreatic cancer (PC), among which BTC mainly includes cholangiocarcinoma (CCA) and gallbladder cancer (GBC), and their prognosis is poor because of the lack of effective early diagnostic methods. Although surgical resection is the preferred method for a cure, treatment options are limited for patients with advanced tumors....
Read the complete abstract on PubMedTopics
- Humans
- Pancreatic Neoplasms
- Tumor Microenvironment
- Amino Acids
- Macrophages