Article

A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis

2021-06-02

Abstract excerpt

<title>Abstract</title> <p>RMRP encodes a non-coding RNA forming the core of the RNase MRP ribonucleoprotein complex. Mutations cause Cartilage Hair Hypoplasia (CHH), characterized by skeletal abnormalities and impaired T cell activation. Yeast RNase MRP cleaves a specific site in the pre-ribosomal RNA (pre-rRNA) during ribosome synthesis. CRISPR-mediated disruption of RMRP in human cells lines caused growth arre...

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Literature Corpus work: 5caf8c5c-80a9-55cc-a5a5-df39c28e29ee
DOI: 10.21203/rs.3.rs-491952/v1

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