Article

A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis

2021-03-29

Abstract excerpt

RMRP encodes a non-coding RNA forming the core of the RNase MRP ribonucleoprotein complex. Mutations cause Cartilage Hair Hypoplasia (CHH), characterized by skeletal abnormalities and impaired T cell activation. Yeast RNase MRP cleaves a specific site in the pre-ribosomal RNA (pre-rRNA) during ribosome synthesis. CRISPR-mediated disruption of RMRP in human cells lines caused growth arrest, with pre-rRNA accumulat...

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Literature Corpus work: 90edd2c1-eae7-53b5-a519-dbce773eb863
DOI: 10.1101/2021.03.29.437572

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