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Article

A novel experimental approach for the selective isolation and characterization of human RNase MRP.

RNA biology - 1 Jan 2022

Derksen Merel, Mertens Vicky, Visser Eline A, Arts Janine, Vree Egberts Wilma, Pruijn Ger J M

Abstract excerpt

RNase MRP is a ribonucleoprotein complex involved in the endoribonucleolytic cleavage of different RNAs. Mutations in the RNA component of the RNP are the cause of cartilage hair hypoplasia. Patients with cartilage hair hypoplasia are characterized by skeletal dysplasia. Biochemical purification of RNase MRP is desired to be able to study its biochemical function, composition and activity in both healthy and...

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Identifiers

PMID: 35129080
DOI: 10.1080/15476286.2022.2027659
PMCID: PMC8820802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel experimental approach for the selective isolation and characterization of human RNase MRP.PMID 35129080Read ↗

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