Article

Spatial Logic Reconciles Gene-signature Methods in Triple Negative Breast Cancer

2026-08-14

Abstract excerpt

Triple-Negative Breast Cancer (TNBC) presents a significant clinical challenge due to its heterogeneity and lack of targeted treatment options, with chemotherapy and immunotherapy combinations currently serving as the main therapeutic strategy. Efforts to address TNBC heterogeneity have largely focused on classifying intrinsic cancer subtypes based on differential tumor mRNA expression, a strategy that has proven...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ef6d667f-99c5-5af9-a1c8-5488d9278955
DOI: 10.64898/2026.08.13.744259

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial Logic Reconciles Gene-signature Methods in Triple Negative Breast CancerDOI 10.64898/2026.08.13.744259Read

Spatial transcriptomics reveals substantial heterogeneity in triple-negative breast cancer with potential clinical implicationsSemantic proximity Read

Spatial transcriptomics reveals substantial heterogeneity in triple negative breast cancer with potential clinical implicationsSemantic proximity Read

Spatially distinct cellular and molecular landscapes define prognosis in triple negative breast cancerSemantic proximity Read

Unraveling Heterogeneity of Tumor Cells and Microenvironment and Its Clinical Implications for Triple Negative Breast CancerSemantic proximity Read

Multi-omics analyses of the heterogenous immune microenvironment in triple-negative breast cancer implicate UQCRFS1 potentiates tumor progressionSemantic proximity Read

Spatial Transcriptomic Analysis of a Diverse Patient Cohort Reveals a Conserved Architecture in Triple-Negative Breast CancerSemantic proximity Read

Machine learning analysis reveals tumor heterogeneity and stromal-immune niches in breast cancerSemantic proximity Read

Unraveling Triple-Negative Breast Cancer Tumor Microenvironment Heterogeneity: Towards an Optimized Treatment ApproachSemantic proximity Read

Single-cell RNA-seq data reveals TNBC tumor heterogeneity through characterizing subclone compositions and proportionsSemantic proximity Read

SMART: A Spatio-Molecular Atlas of Response Trajectories in Triple-Negative Breast CancerSemantic proximity Read

Integrated Analysis of Single-Cell and Bulk RNA-Seq Data reveals that Ferroptosis-Related Genes Mediated the Tumor Microenvironment predicts Prognosis, and guides Drug Selection in Triple-Negative Breast CancerSemantic proximity Read

Targeted spatial profiling identifies a CD8A − LARS axis associated with neoadjuvant chemotherapy resistance in triple-negative breast cancerSemantic proximity Read