Article

Global DNA hypomethylation in epithelial ovarian cancer: passive demethylation and association with genomic instability

2020-01-27

Abstract excerpt

A hallmark of human cancer is global DNA hypomethylation (GDHO), but the mechanisms accounting for this defect and its pathological consequences have not been defined in human epithelial ovarian cancer (EOC). In EOC, GDHO was associated with advanced disease and reduced overall and disease-free survival. GDHO(+) EOC was enriched for a proliferative gene expression signature, including CCNE1 and FOXM1 overexpressio...

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Literature Corpus work: d8c655bc-d860-5025-a8f2-bfd39291a8cd
DOI: 10.1101/2020.01.22.20018374

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