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Genome-wide DNA methylome analysis identifies methylation signatures associated with survival and drug resistance of ovarian cancers

22 Jul 2021

Abstract excerpt

BACKGROUND: In contrast to stable genetic events, epigenetic changes are highly plastic and play crucial roles in tumor evolution and development. Epithelial ovarian cancer (EOC) is a highly heterogeneous disease that is generally associated with poor prognosis and treatment failure. Profiling epigenome-wide DNA methylation status is therefore essential to better characterize the impact of epigenetic alterations...

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PMID: 34294135
DOI: 10.1186/s13148-021-01130-5

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