Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution.

Nature communications - 24 May 2016

Bartlett Thomas E, Chindera Kantaraja, McDermott Jacqueline, Breeze Charles E, Cooke William R, Jones Allison, Reisel Daniel, Karegodar Smita T, Arora Rupali, Beck Stephan, Menon Usha, Dubeau Louis, Widschwendter Martin

Abstract excerpt

The exact timing and contribution of epigenetic reprogramming to carcinogenesis are unclear. Women harbouring BRCA1/2 mutations demonstrate a 30-40-fold increased risk of high-grade serous extra-uterine Müllerian cancers (HGSEMC), otherwise referred to as 'ovarian carcinomas', which frequently develop from fimbrial cells but not from the proximal portion of the fallopian tube. Here we compare the DNA methylome of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AICDA (Activation-Induced Cytidine Deaminase)
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to Cytidine Deaminase

Share to Epithelium

Share to Fallopian Tubes

Share to Ovariectomy

Share to Primary Cell Culture

Source

Open in PubMed Open full text

Identifiers

PMID: 27216078
DOI: 10.1038/ncomms11620
PMCID: PMC4890182

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution.PMID 27216078Read ↗

The tubal epigenome - An emerging target for ovarian cancer.Semantic proximity Read ↗

DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnosticsSemantic proximity Read ↗

Spatial Transcriptomic Analysis of Ovarian Cancer Precursors Reveals Reactivation of IGFBP2 during PathogenesisSemantic proximity Read ↗

Unveiling DNA methylation: early diagnosis, risk assessment, and therapy for endometrial cancerSemantic proximity Read ↗

DNA methylation changes in ovarian cancer: Implications for early diagnosis, prognosis and treatmentSemantic proximity Read ↗

The DNA methylome of cervical cells can predict the presence of ovarian cancer.Semantic proximity Read ↗

Comparative DNA methylome analysis of endometrial carcinoma reveals complex and distinct deregulation of cancer promoters and enhancers.Semantic proximity Read ↗

Methylomic Analysis of Ovarian Cancers Identifies Tumor-Specific Alterations Readily Detectable in Early Precursor LesionsSemantic proximity Read ↗

A cell-of-origin epigenetic tracer reveals clinically distinct subtypes of high grade serous ovarian cancerSemantic proximity Read ↗

Differential analysis of ovarian and endometrial cancers identifies a methylator phenotype.Semantic proximity Read ↗

Lineage-Specific Epigenomic Mapping of Proximal and Distal Fallopian Tube Epithelium Reveals Mesenchymal/Wnt-Driven Tumor Phenotype DiversificationSemantic proximity Read ↗

Identification of endometrial cancer methylation features using combined methylation analysis methods.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.