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Article

PPARγ/ETV2 axis regulates endothelial‐to‐mesenchymal transition in pulmonary hypertension

1 Oct 2024

Abstract excerpt

Abstract Endothelial‐to‐mesenchymal transition (EndoMT) plays an important role in pulmonary hypertension (PH) but the molecular mechanisms regulating EndoMT remain to be defined. We demonstrate that the axis of the transcription factors PPARγ (Peroxisome Proliferator‐Activated Receptor gamma) and ETV2 (ETS variant 2) play important roles in the pathogenesis of PH. Decreased levels of the expression of PPARγ and...

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Share to Cardiovascular Function and Risk Factors
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PMID: 39391221
DOI: 10.1002/pul2.12448

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