Article

Functional divergence of WWC family proteins in human endothelial cells

2026-08-24

Abstract excerpt

The Hippo signaling pathway is increasingly recognized as a key regulator of endothelial cell (EC) proliferation, migration and vascular development. However, the roles of its upstream scaffold proteins remain poorly understood. Although WWC family proteins are widely regarded as functionally redundant activators of LATS1/2 kinases, the human genome contains a third family member, WWC3, that is absent from mice, r...

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Literature Corpus work: d8b24bdd-395c-5309-a092-e10e739ab35d
DOI: 10.64898/2026.08.21.746351

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