Article

N6-methyladenosine reader RBMX is essential for motor cortex excitatory neuron survival in amyotrophic lateral sclerosis

2023-04-25

Abstract excerpt

Despite being one of the most common RNA modifications, the role of N6-methyladenosine (m6A) in amyotrophic lateral sclerosis (ALS) remains incompletely understood. The present study aims to explore the involvement of RBMX -mediated m6A posttranscriptional regulation in ALS pathophysiology. We examined the cellular effects of downregulating Rbmx in murine motor neuron cell line NSC-34, and the transcriptomic chang...

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Literature Corpus work: d8acb2ae-17da-5ded-82d9-530a066b92ca
DOI: 10.21203/rs.3.rs-2716005/v1

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