Article
Epigenetic Mechanisms of Gene Regulation in Amyotrophic Lateral Sclerosis.
Advances in experimental medicine and biology - 1 Jan 2017
Jimenez-Pacheco Alba, Franco Jaime M, Lopez Soledad, Gomez-Zumaquero Juan Miguel, Magdalena Leal-Lasarte Maria, Caballero-Hernandez Diana E, Cejudo-Guillén Marta, Pozo David
Abstract excerpt
Despite being clinically described 150 years ago, the mechanisms underlying amyotrophic lateral sclerosis (ALS) pathogenesis have not yet been fully understood. Studies in both animal models of ALS and human patients reveal a plethora of alterations such as increased glutamate-mediated excitotoxicity, redox stress, increased apoptosis, defective axonal transport, protein-misfolding events, mitochondrial...
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