Article

Development and characterization of mouse-adapted recombinant SARS-CoV-2 expressing reporter genes

2026-02-16

Abstract excerpt

Transgenic K18-hACE2 mice are a standard model for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), albeit with limitations. A mouse-adapted 30 (MA30) SARS-CoV-2 has been developed to allow infection of wild-type (WT) mice strains. However, SARS-CoV-2 MA30 cannot be easily tracked in vitro , ex vivo , or in vivo . To address the problem, we developed a recombinant (r)SARS-CoV-2 based on the MA30 st...

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Literature Corpus work: d88a6002-af3a-54dc-80ab-2cfb3474c841
DOI: 10.64898/2026.02.04.703885

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