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Article

Fluorescent and Bioluminescent Reporter Mouse-Adapted Ebola Viruses Maintain Pathogenicity and Can Be Visualized in Vivo.

The Journal of infectious diseases - 15 Nov 2023

Davies Katherine A, Welch Stephen R, Jain Shilpi, Sorvillo Teresa E, Coleman-McCray JoAnn D, Montgomery Joel M, Spiropoulou Christina F, Albariño César, Spengler Jessica R

Abstract excerpt

Ebola virus (EBOV) causes lethal disease in humans but not in mice. Here, we generated recombinant mouse-adapted (MA) EBOVs, including 1 based on the previously reported serially adapted strain (rMA-EBOV), along with single-reporter rMA-EBOVs expressing either fluorescent (ZsGreen1 [ZsG]) or bioluminescent (nano-luciferase [nLuc]) reporters, and dual-reporter rMA-EBOVs expressing both ZsG and nLuc. No detriment...

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Identifiers

PMID: 37145895
DOI: 10.1093/infdis/jiad136
PMCID: PMC11014640

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