Article

A Mouse Model of SARS-CoV-2-Driven Acute Maladaptive Responses and Chronic Systemic Diseases

2025-08-13

Abstract excerpt

<h4>ABSTRACT</h4> Our understanding of SARS-CoV-2 acute and post-acute pathogenesis is hindered by the lack of adequate small animal models. We present RAB/6N, a mouse model prone to severe disease after exposure to SARS-CoV-2 clinical isolates, with lethal cases showing no widespread brain infection typical of the widely used K18-hACE2 mouse model. Lung viral replication in RAB/6N mice remains steady for several...

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Literature Corpus work: 5cc156e2-f923-515c-9d83-55d47381f450
DOI: 10.1101/2025.08.13.670105

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