Article

A direct link between <i>Prss53</i> , hair curvature, and skeletal dysplasia

2019-02-25

Abstract excerpt

In humans, protease serine S1 family member 53 (Prss53) is highly expressed in the hair follicle, especially the inner root sheath, which is associated with hair shape according to recent genome-wide association study (GWAS) data. However, no animal evidence has indicated a link between Prss53 and hair shape to date. Here, we used CRISPR/Cas9 to generate Prss53 -mutated rabbits. The homozygous ( Prss53 -/- ) ra...

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Literature Corpus work: d87ff435-2e10-5ebb-b402-3a6b9c9b83e8
DOI: 10.1101/560847

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