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Analysis of 470,000 exome-sequenced UK Biobank participants identifies genes containing rare variants which confer dementia risk

2024-11-26

Abstract excerpt

<h4>Background</h4> Previous studies have reported that rare coding variants in a handful of genes have major effects on risk of Alzheimer’s disease (AD). A recent exome wide association study (ExWAS) of dementia in a subset of the UK Biobank cohort implicated a number of genes, including five which were novel. Here we report a similar analysis, carried out on the full cohort of 470,000 exome-sequenced participant...

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Literature Corpus work: 00b6aec0-a22c-5606-983a-3cb1494520ec
DOI: 10.1101/2024.11.25.24317885

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