Article

More than 100 dual coding regions have evidence for selection constraints in both reading frames

2026-05-29

Abstract excerpt

Alternative splicing can generate multiple differently spliced transcripts from a single pre-mRNA. A striking number of genes have alternative splice events that ccan hange the downstream reading frame leading to exons that code from distinct reading frames. In fact, more than a third of the coding genes in the human gene set are annotated with dual coding exons derived from alternative splicing events. Here we an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d877a0ad-ed20-57b2-bcf1-67d2114ed5e4
DOI: 10.64898/2026.05.28.727796

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

More than 100 dual coding regions have evidence for selection constraints in both reading framesDOI 10.64898/2026.05.28.727796Read

Alternatively Spliced Dual-Coding Regions Contribute to the Human Gene Regulatory ProgramSemantic proximity Read

Ancient origins of complex neuronal genesSemantic proximity Read

Alternative splicing as a source of phenotypic diversity.Semantic proximity Read

Genome-wide annotation and analyses of bifunctional genes in the human genomeSemantic proximity Read

The evolutionary landscape of alternative splicing in vertebrate species.Semantic proximity Read

Structural variation, selection, and diversification of the <i>NPIP</i> gene family from the human pangenomeSemantic proximity Read

De novo origin of human protein-coding genes.Semantic proximity Read

TrkA alternative splicingSemantic proximity Read

Large-scale identification and characterization of alternative splicing variants of human gene transcripts using 56,419 completely sequenced and manually annotated full-length cDNAs.Semantic proximity Read

Alternative splicing in the nervous system: an emerging source of diversity and regulation.Semantic proximity Read

Cross-tissue isoform switches by human transcription factors suggest a widespread regulatory mechanismSemantic proximity Read

Systematic detection of brain protein-coding genes under positive selection during primate evolution and their roles in cognitionSemantic proximity Read