Article

Myeloid cell-specific deletion of Capns1 prevents macrophage polarization toward the M1 phenotype and reduces interstitial lung disease in systemic sclerosis

2021-03-30

Abstract excerpt

<title>Abstract</title> <p>Background Calpains are a family of calcium-dependent thiol proteases that participate in a wide variety of biological activities. In our recent study, calpain is increased in the sera of scleroderma or systemic sclerosis (SSc). However, the role of calpain in interstitial lung disease (ILD) has not been reported. ILD is a severe complication of SSc, which is the leading cause of death...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0c584fc6-1083-5754-808e-04660d4717ff
DOI: 10.21203/rs.3.rs-342595/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Myeloid cell-specific deletion of Capns1 prevents macrophage polarization toward the M1 phenotype and reduces interstitial lung disease in systemic sclerosisDOI 10.21203/rs.3.rs-342595/v1Read

Myeloid cell-specific deletion of Capns1 prevents macrophage polarization toward the M1 phenotype and reduces interstitial lung disease in the bleomycin model of systemic sclerosis.Semantic proximity Read

Increased serum calpain activity is associated with HMGB1 levels in systemic sclerosisSemantic proximity Read

ACSL4 Inhibition Prevents Macrophage Ferroptosis and Alleviates Fibrosis in Bleomycin-induced Systemic Sclerosis ModelSemantic proximity Read

CAPN3: A muscle‑specific calpain with an important role in the pathogenesis of diseases (Review)Semantic proximity Read

SPARC regulation of PMN clearance protects from pristane induced lupus and rheumatoid arthritisSemantic proximity Read

The Calpain System as a Modulator of Stress/Damage ResponseSemantic proximity Read

Redox-Dependent Calpain Signaling in Airway and Pulmonary Vascular Remodeling in COPD.Semantic proximity Read

[A Uuifying hypothesis for the pathogenesis of systemic sclerosis based on the deficiency of transcription factor Fli1 - the development of a new animal model of systemic sclerosis -].Semantic proximity Read

Eosinophilic infiltration related to CAPN3 mutations: a pathophysiological component of primary calpainopathy?Semantic proximity Read

Fli1 deficiency suppresses RALDH1 activity of dermal dendritic cells and related induction of regulatory T cells: a possible role in sclerodermaSemantic proximity Read

ALPN-101 (Acazicolcept) a Dual ICOS/CD28 Antagonist, Demonstrates Efficacy in Systemic Sclerosis Preclinical Mouse ModelsSemantic proximity Read

m-Calpain is required for preimplantation embryonic development in mice.Semantic proximity Read