Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell multi-omics analysis identifies SPP1+ macrophages as key drivers of ferroptosis-mediated fibrosis in ligamentum flavum hypertrophy

25 Feb 2025

Abstract excerpt

Abstract Background Ligamentum flavum hypertrophy (LFH) is a primary contributor to lumbar spinal stenosis. However, a thorough understanding of the cellular and molecular mechanisms driving LFH fibrotic progression remains incomplete. Methods Single-cell RNA sequencing (scRNA-seq) was performed to construct the single-cell map of human ligamentum flavum (LF) samples. An integrated multi-omics approach,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cervical and Thoracic Myelopathy
Share to Spine and Intervertebral Disc Pathology
Share to Spondyloarthritis Studies and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40001138
DOI: 10.1186/s40364-025-00746-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell multi-omics analysis identifies SPP1+ macrophages as key drivers of ferroptosis-mediated fibrosis in ligamentum flavum hypertrophyPMID 40001138Read ↗

Single‐cell RNA sequencing reveals the CRTAC1 + population actively contributes to the pathogenesis of spinal ligament degeneration by SPP1 + macrophageSemantic proximity Read ↗

CRLF1 Is a Key Regulator in the Ligamentum Flavum HypertrophySemantic proximity Read ↗

Identification of pro-fibrotic cellular subpopulations in fascia of gluteal muscle contracture using single-cell RNA sequencingSemantic proximity Read ↗

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosisSemantic proximity Read ↗

Immune cell infiltration and the genes associated with ligamentum flavum hypertrophy: Identification and validationSemantic proximity Read ↗

Systems Level Identification of a Matrisome-Associated Macrophage Polarization State in Multi-Organ FibrosisSemantic proximity Read ↗

Identifying Key Cells for Fibrosis by Systematically Calling Cell Type–Phenotype Associations across Massive Heterogenous DatasetsSemantic proximity Read ↗

Single-cell transcriptome and multi-omics integration reveal ferroptosis-driven immune microenvironment remodeling in knee osteoarthritisSemantic proximity Read ↗

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosisSemantic proximity Read ↗

Circular RNA Expression Profile in Patients with Lumbar Spinal Stenosis Associated with Hypertrophied Ligamentum FlavumSemantic proximity Read ↗

A single-cell atlas depicting the cellular and molecular features in human ligamental degeneration: a single cell combined spatial transcriptomics studySemantic proximity Read ↗

Fibroblast Iron Metabolic Reprogramming Links Chronic Inflammation to Extracellular Matrix Remodeling and Pathological OssificationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.