Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration

3 Jul 2025

Abstract excerpt

Abstract Age-related macular degeneration (AMD), a multifactorial type of retinal degeneration represents the most common cause for blindness in elderly. Polymorphisms in complement factor-H increase, while absence of factor-H-related protein-1 (FHR1) decreases the AMD risk, currently explained by their opposing relationship. Here we identify a FHR1-driven pathway fostering chronic cellular inflammation. FHR1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Retinal Development and Disorders
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40611130
DOI: 10.1186/s12974-025-03499-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degenerationPMID 40611130Read ↗

<i>CFH</i> loss in human RPE cells leads to inflammation and complement system dysregulation <i>via</i> the NF-κB pathwaySemantic proximity Read ↗

CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-κB PathwaySemantic proximity Read ↗

Interlink between Inflammation and Oxidative Stress in Age-Related Macular Degeneration: Role of Complement Factor HSemantic proximity Read ↗

Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration.Semantic proximity Read ↗

The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited.Semantic proximity Read ↗

Identification of Factor H–like Protein 1 as the Predominant Complement Regulator in Bruch’s Membrane: Implications for Age-Related Macular DegenerationSemantic proximity Read ↗

The Noncanonical Role of Complement Factor H in Retinal Pigment Epithelium (RPE) Cells and Implications for Age-Related Macular Degeneration (AMD).Semantic proximity Read ↗

Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular degeneration.Semantic proximity Read ↗

Beyond factor H: The impact of genetic-risk variants for age-related macular degeneration on circulating factor-H-like 1 and factor-H-related protein concentrations.Semantic proximity Read ↗

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration.Semantic proximity Read ↗

Factor H‐related protein 1: a complement regulatory protein and guardian of necrotic‐type surfacesSemantic proximity Read ↗

Non-canonical roles of CFH in retinal pigment epithelial cells revealed by dysfunctional rare CFH variantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.