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Declining RNA integrity in control autopsy brain tissue is robustly and asymmetrically associated with selective neuronal mRNA signal loss

2021-09-07

Abstract excerpt

RNA integrity numbers (RINs) are a standardized method for semi-quantification of RNA degradation, and are used in quality control prior to transcriptional profiling analysis. Recent work has demonstrated that RINs are associated with downstream transcriptional profiling, and correction procedures are typically employed in bioinformatic analysis pipelines to attempt to control for RIN’s influence on gene expressio...

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Literature Corpus work
d848384d-6814-5a4c-8734-a35ed32fc76d
DOI
10.1101/2021.09.07.459326
Open publication

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Declining RNA integrity in control autopsy brain tissue is robustly and asymmetrically associated with selective neuronal mRNA signal lossDOI 10.1101/2021.09.07.459326
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