Article

Agonal factors distort gene-expression patterns in human postmortem brains

2020-07-12

Abstract excerpt

Agonal factors, the conditions that occur just prior to death, can impact the molecular quality of postmortem brains, influencing gene expression results. Nevertheless, study designs using postmortem brain tissue rarely, if ever, account for these factors, and previous studies had not documented nor adjusted for agonal factors. Our study used gene expression data of 262 samples from ROSMAP with the following termi...

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Literature Corpus work: 54b7a4ab-bed5-5ce9-bb65-0f73faaad40a
DOI: 10.1101/2020.07.11.198523

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