An analysis of RNA quality metrics in human brain tissue

Abstract excerpt

Human brain tissue studies have historically used a range of metrics to assess RNA quality. However, few large-scale cross-comparisons of pre-sequencing quality metrics with RNA-seq quality have been published. Here, we analyze how well metrics gathered before RNA sequencing (post-mortem interval (PMI) and RNA integrity number RIN) relate to analyses of RNA quality after sequencing (Percent of counts in Top Ten ge...

Topics

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• Alleles
• Brain
• Gene Expression Profiling
• Polymorphism, Single Nucleotide
• RNA Isoforms
• RNA, Untranslated
• Sequence Analysis, RNA
• Smoking

Identifiers and source

Literature Corpus work

84cfe11c-e5bd-56af-8eb8-ba0917b9337b

DOI

10.1101/2024.10.14.618253